4U liquid-cooled GPU SuperServer with 8× AMD Instinct MI355X or MI325X OAM accelerators, dual AMD EPYC 9005/9004 CPUs up to 500W, and AMD Infinity Fabric Link. Announced the day AMD introduced the MI350 series.
4U Rackmount (CSE-GP403TS-R000NP2)
Up to 8× AMD Instinct MI355X or MI325X OAM
AMD Infinity Fabric Link
PCIe 5.0 x16
Dual AMD EPYC 9005/9004, up to 384C/768T, up to 500W (liquid-cooled)
Super H14DSG-OD
24× DIMM, up to 6TB DDR5-6400 ECC RDIMM (1DPC)
8× front hot-swap 2.5" NVMe + 2× M.2 boot
8× PCIe 5.0 x16 LP + 2× PCIe 5.0 x16 FHHL
2× RJ45 10GbE + dedicated IPMI 2.0
Direct-to-chip cold plate + 5 heavy-duty fans
4× 6600W Titanium (96%) 2+2 redundant
174 × 449 × 895.35 mm (6.85" × 17.6" × 35.25")
80 lbs (53 kg) net / 140 lbs (63.5 kg) gross
AMD ROCm open software stack
Available
Quote
The Supermicro AS-4126GS-NMR-LCC is a liquid-cooled 4U GPU SuperServer purpose-built for AMD's Instinct MI350-series accelerators. It carries up to eight MI355X (or MI325X) OAM GPUs interconnected via AMD Infinity Fabric Link, with PCIe 5.0 x16 CPU-to-GPU links into dual EPYC 9005/9004 processors running up to 500W under direct-to-chip liquid cooling.
SuperMicro announced this system the same day AMD formally launched the Instinct MI350 series, positioning it for AI training and inference at scale with a lower total cost of ownership than comparable platforms. It supports up to 6TB of DDR5-6400 ECC memory across 24 DIMMs, eight front hot-swap NVMe bays, and four redundant 6600W Titanium PSUs — a dense, building-block foundation for AMD-based AI factories.
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